Max dose 5mg.Ĭonsider giving NovoSeven RT 90 micrograms/kg IV (alternate choice). Vitamin K 30 mcg/kg IV by slow IV infusion over 10-20 minutes (to avoid anaphylaxis).
Life threatening and will cause morbidity: If INR1.5 or bleeding not controlled, contact the Coagulation Consult Service immediately.Check INR stat 30 minutes after end of Kcentra infusion:.Administer with vitamin K concurrently.Vitamin K 30 mcg/kg by slow IV infusion over 10-20 minutes (to avoid anaphylaxis). Not life threatening and will not cause morbidity: The preferred route is IV, but in a child with poor or no venous access, the PO or SQ route may be used, particularly if the INR is 6-10. Oral vitamin K is effective in adults but the INR fall is slower than IV injection. Seriously ill children with liver dysfunction may require more than a single dose. Even 0.5mg (sufficient for many adults) is likely to be too high for most young children.
This weight adjusted regimen is safer for pediatric patients than a universal dosage (i.e. Vitamin K 30 mcg/kg by slow IV infusion over 10-20 minutes (to avoid anaphylaxis). If patient requires rapid warfarin reversal but has no bleeding, insignificant bleeding or bruising: significant bleeding and need for future warfarin therapy. Choice and dose is dependent on the clinical problem-no bleeding vs.
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